Blar i forfatter "Sharma, Suraj"

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    • Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria 

      Sharma, Suraj; Hsieh, Yin-Chen; Dietze, Jørn; Bockwoldt, Mathias; Strømland, Øyvind; Ziegler, Mathias; Heiland, Ines (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-21)
      Bacteria use two alternative pathways to synthesize nicotinamide adenine dinucleotide (NAD) from nicotinamide (Nam). A short, two-step route proceeds through nicotinamide mononucleotide (NMN) formation, whereas the other pathway, a four-step route, includes the deamidation of Nam and the reamidation of nicotinic acid adenine dinucleotide (NAAD) to NAD. In addition to having twice as many enzymatic ...

    • Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production 

      Mohapatra, Soumya R; Sadik, Ahmed; Sharma, Suraj; Poschet, Gernot; Gegner, Hagen M; Lanz, Tobias V; Lucarelli, Philippe; Klingmüller, Ursula; Platten, Michael; Heiland, Ines; Opitz, Christiane A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-19)
      The liver is the central hub for processing and maintaining homeostatic levels of dietary nutrients especially essential amino acids such as tryptophan (Trp). Trp is required not only to sustain protein synthesis but also as a precursor for the production of NAD, neurotransmitters and immunosuppressive metabolites. In light of these roles of Trp and its metabolic products, maintaining homeostatic ...

    • Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma 

      Sharma, Suraj; Heiland, Ines; Panitz, Verena; Koncarevic, Sasa; Sadik, Ahmed; Friedel, Dennis; Bausbacher, Tobias; Trump, Saskia; Farztdinov, Vadim; Schulz, Sandra; Sievers, Philipp; Schmidt, Stefan; Jürgenson, Ina; Jung, Stephan; Kuhn, Karsten; Pflüger, Irada; Wick, Antje; Pfänder, Pauline; Selzer, Stefan; Vollmuth, Philipp; Sahm, Felix; von deimling, Andreas; Hopf, Carsten; Schulz-Knappe, Peter; Pike, Ian; Platten, Michael; Wick, Wolfgang; Opitz, Christiane A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-03)
      Tryptophan (Trp)-catabolic enzymes (TCEs) produce metabolites that activate the aryl hydrocarbon receptor (AHR) and promote tumor progression and immunosuppression in glioblastoma. As therapies targeting TCEs or AHR become available, a better understanding of Trp metabolism is required.<p> <P>Methods: The combination of LC-MS/MS with chemical isobaric labeling enabled the simultaneous quantitative ...